This document is intended to serve as a guide for application development with EZRadioPRO® radio ICs. It introduces the major parts of the hardware platform, such as the RF Pico board, which contains the radio and the necessary RF components required to operate the device according to a desired regulatory standard. It also introduces the 8-bit wireless motherboard (WMB), which is required to control the radio, evaluate the RF parameters, and develop custom application programs. Besides the hardware, it also describes the application programming interface (API) that makes it possible for the WMB and RF pico board to communicate with each other. Using the software tools provided by Silicon Labs and following this programming guide will make software development as easy as possible, as these items will assist you in configuring the radio effectively. Additionally, the first boot of the radio and the whole configuration process are clearly described so that software developers can primarily concentrate on their own applications without experiencing time-consuming configuration problems. Several example projects are also provided as good starting points for real applications. A layered software approach is followed in all the source codes. The software modules are logically separated, and they focus on their own specific tasks. The document refers to the corresponding data sheets, manuals, and application notes.